Full text full text is available as a scanned copy of the original print version get a printable copy pdf file of the complete article 447k or click on a page image below to browse page by page. Pdf on jan 22 1977 ri ogilvie published evaluations of drug interactions find read and cite all the research you need on researchgate. Needless to say it is crucial in the development of pharmaceutical products to appropriately assess the potential and extent of so called pharmacokinetic drug drug interactions ddi in which adverse effects occur when multiple drugs are combined by affecting one drugs pharmacokinetics absorption distribution metabolism and excretion by the other. Evaluation of drug interaction reports drug dosing 2015 04 09 090450 john r horn pharmd fccp and philip d hansten pharmd when evaluating a published report of a potential drug drug interaction it is important to consider the variables that are likely to affect the magnitude of the interaction