Vitamin d and chronic kidney disease chronic kidney disease ckd has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality vitamin d deficiency or insufficiency is common in patients with ckd and serum levels of vitamin d appear to have an inverse cor . Hyperparathyroidism occurs in most patients during the progression of chronic kidney disease ckd and one of its initiating events reduced serum levels of 125 dihydroxyvitamin d results from a decrease in renal 1 hydroxylase activity which converts 25 hydroxyvitamin d to its activated form the combination of persistently high parathyroid hormone pth and low 125 dihydroxyvitamin d is associated with bone loss cardiovascular disease immune suppression and increased mortality in . Vitamin d and chronic kidney disease davita vitamin d is necessary for good healthyet people with chronic kidney disease ckd and those who have end stage renal disease esrd and are on dialysis may not be getting enough vitamin d is activated in the kidneys so those with kidney failure may need medicines to get their dose of vitamin d. Chronic kidney disease ckd has been recognized as a significant public health problem with